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Welcome to Arise Infectious Disease Project

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Infections

A Pathogen is a microorganism that causes diseases. Susceptible means likely to get infected. A Host is a place where pathogens live. A Disease is an illness caused by a bacteria or a virus.

Virus & Bacteria

There are many biological difference between a Bacteria & Virus. The first difference is that a Bacteria has only DNA as their genetic material while Viruses can either have RNA or DNA as their genetic material. Both pathogens are also consider differently in their state of life. Bacteria are considered to be alone due to them following all The 7 Characteristics of life. On the contrast Viruses do not follow all 7 of these characteristic so they are considered nonliving. The main difference between both pathogen is that a illness caused by a bacteria can be cured with Antibiotics. However an illness caused by a virus can’t be cured it can only be treated.

Chain of Infection

The Chain of Infection are conditions that must exist for a disease occur and spread. The chain of infection is divided into 6 different parts. The chain of infection begins with a Causative Agent which is a pathogen that can cause a disease. The second part of the chain is the Reservoir where the pathogen can live. These can include the human body, animal and fomites. The third part of the chain is the Portal of Exit which is the way it pathogen leaves the reservoir. Some ways the pathogen can leave the reservoir include through urine feces, saliva and open wound. The fourth part of the chain is the Mode of Transmission which is the way that pathogens are transmitted to a host. Such ways include direct contact between persons, & indirect contact like contaminated areas or substances. The fifth part of the chain is the Portal of Entry which is the way a pathogen enters a host. Some ways the pathogen can enter a host include breaks in the skin, the respiratory tract, the digestive tract and the circulatory track. The final part of the chain is the Susceptible Host which is an individual who can contact the disease. Humans can become susceptible host when a large amount of pathogen enter their bodies or if they have a weak immune system. There many some ways to break the Chain of Infection in order to prevent infections from occurring. Some ways include being careful on what you make direct contact with and being careful on what goes inside your body. There is also making sure that you have a healthy body in order to help the immune system fight of pathogen that have enter the body.

Types of Infections

Their is 4 different types of infections that can occur. The first type of infection are Endogenous Infections which is when a infection or disease originates from within the body. Some examples include tumors, birth defects and metabolic disorder. The second type of infection are Exogenous Infections which is when a infection or disease originates from outside the body. This can include chemicals, Trauma, Electric Shock and Pathogenic organisms. The third type of infection are Nosocomial Infections which is a infection acquired by an individual in a healthcare facility. This type of infections are usually present in a facility and are transmitted by healthcare workers to a patient. The final type of infection are Opportunistic Infections which are infection that occur when the body defense are weak.

Researchers

There are currently many different amount of people researching how to cure the HIV virus, better treatment and gain more knowledge on it. These people are constantly working every single day of their career life in order to help advance the knowledge on the HIV virus together. It starts with those who study the virus expanding on what it does and it design. Then it goes to those who are looking for a treatment for the virus. They are constantly attacking the virus with many different drugs in order to see which one are more effective and which ones have the better combination of others. Their findings are then passed down to those who looking for a cure in order to find a drug that will kill the virus. All of these people are constantly in danger due to them being near the virus & one misstep can have serious consequences such as being infected or loosing all of the research.

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HIV/AIDS

About HIV/AIDS

HIV is lentivirus that turns into AIDS over time. HIV standing for Human Immunodeficiency Virus & AIDS standing for Acquired Immune Deficiency Syndrome.  This virus looks like small ball cover all around with towers with suction cups at the top.


There is many ways to transmit the HIV virus. The most common ways being through bodily fluids & unprotected sexual intercourse. This body fluids include blood, semen, pre-seminal fluids, rectal fluids, raginal fluids. Most of these bodily fluids are transmitted through sexual intercourse where no protection is used.


Once infected by this virus through these fluids it will enter a dormant state making impossible for people to know that they have been infected. After 2-4 weeks of being infected the host will start showing symptoms of having the HIV virus. The virus will remain inside the host attacking the immune system. Once infected with the virus it will remain inside the host until its host death. During this time the virus will weaken the immune system increasing the chances for the host to construct more infections. The most deadly being AIDS.

Take some time to explore the blog, read something interesting, and feel free to reach out if you would like to collaborate on a project together.

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Immune System Response

The HIV virus is a virus that attacks a person's immune system weakening it & killing the CD4 cells or T cells. There are 2 different kinds of T cells; killer T-cells & helper T-cells. The first type of T-cells are Killer T-cells which are capable of hunting down pathogens and killing them. They attack the pathogens in large amount dissolving its outer layer and entering it killing it from the inside. The second type of T-cells are Helper T-cells which help regulate the attack. These cells are able to activate killer T-cells & suppressed the invading pathogen by attaching to it.


In response to the virus the immune system release a protein to stop it from replicating and spreading throughout the body. However upon entering the HIV virus release a protein called VPU. VPU standing for Viral Protein U. This protein disables all the defense mechanism of the protein released from the immune system making it useless & allowing for the virus to spread. Thus there is nothing the immune system can do to fight back against the Virus.

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Defenses Available

Behavioral

There are many ways to stop the transmission of the HIV virus but there is always the chance for someone to get infected. Some of these ways include to use condoms during intercourse to stop infected bodily fluids from being transmitted to another person. There is also to not share needles with other person in order to stop infected blood from being transmitted. Then there is the one most lily to stop someone from getting infected, not be sexually active to just erase the risk of bodily fluids from being transmitted. Of course all of these help reduce the chance and aren't 100% because there is always the chance of something happening.


Treatment

Currently there is no cure for those who have been infected by the HIV Virus. However there are different treatment a infected person can take to help with the effects of the virus. One of these treatment is ART which stands for Antiretroviral Therapy. The therapy involves taking a combination of drugs in order to lower

the amount of the virus a person's blood & body fluids. It can also help reduce the chances of transmitting HIV to another person.

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Sources

  1. "Cellular scissors chop up HIV virus", Health.am. 12/13/18. http://www.health.am/aids/more/cellular-scissors-chop-up-hiv-virus/

  2. "Difference between DNA and RNA Viruses", Difference btw. 12/13/18. https://www.differencebtw.com/difference-between-dna-and-rna-viruses/amp/

  3. "ANTIRETROVIRAL THERAPY; CURE TO HIV/AIDS?", MedicalMattaz. 12/13/18. http://medicalmattaz.blogspot.com/2015/12/antiretroviral-therapy-cure-to-hivaids.html

  4. "RT, LIKE: How HIV is being transmitted. #FightHIVPhilippines", Twitter. 12/13/18. https://twitter.com/phbisexuals/status/708313477866070020

  5. "HIV Treatment", CDC. 12/13/18. https://www.cdc.gov/hiv/basics/livingwithhiv/treatment.html

  6. "Prevention", CDC. 12/13/18.  https://www.cdc.gov/hiv/basics/prevention.html

  7. "About HIV/AIDS", CDC. 12/13/18. https://www.cdc.gov/hiv/basics/whatishiv.html

  8. "HIV Transmission", CDC. 12/13/18. https://www.cdc.gov/hiv/basics/transmission.html

  9. "Clue to Why Human Body Can't Fight HIV Discovered", LiveScience. 12/13/18. https://www.livescience.com/36558-hiv-human-immunity.html

  10. "T-cell background", Ontario Genomics. 12/13/18. http://www.ontariogenomics.ca/impact-stories/understanding-cancer-causing-cells/attachment/t-cell-background-2/

  11. "HIV/AIDS", CDC, 12/13/18. https://www.cdc.gov/dotw/hiv-aids/index.html

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